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American Society of Microbiology ABMM Sample Questions (Q44-Q49):

NEW QUESTION # 44
A clinical microbiology laboratory is investigating an outbreak of vancomycin-resistantEnterococcus faecium (VRE) in a hospital. Whole-genome sequencing of isolates from different patients reveals the presence of the vanA operon on a mobile genetic element that is highly conserved across all isolates. This finding MOST strongly suggests:

A. Independent acquisition of vancomycin resistance by different E. faecium strains.
B. Horizontal transfer of the vanA operon to multiple susceptible E. faecium strains.
C. Selection of vancomycin-resistant mutants within a susceptible E. faecium population due to antibiotic pressure.
D. Clonal spread of a single VRE strain carrying the vanA operon.

Answer: D

NEW QUESTION # 45
A patient with a prosthetic joint develops a chronic infection. Multiple synovial fluid cultures grow a Gram- positive coccus that forms a biofilm and is resistant to multiple antibiotics, including methicillin and gentamicin. The MOST likely organism is:

A. Staphylococcus epidermidis
B. Staphylococcus aureus
C. Enterococcus faecium
D. Streptococcus agalactiae

Answer: A

NEW QUESTION # 46
A clinical microbiology laboratory is performing antimicrobial susceptibility testing on a Klebsiella pneumoniae isolate. The isolate is resistant to multiple beta-lactam antibiotics, and further testing reveals the presence of a carbapenemase enzyme. The MOST clinically significant carbapenemase in Klebsiella pneumoniae is often:

A. Klebsiella pneumoniae carbapenemase (KPC)
B. Extended-spectrum beta-lactamase (ESBL)
C. Metallo-beta-lactamase (MBL)
D. AmpC beta-lactamase

Answer: A

NEW QUESTION # 47
A patient develops a severe diarrheal illness after returning from a backpacking trip where they drank untreated stream water. Stool examination reveals motile trophozoites with multiple flagella and a prominent ventral sucking disk. The MOST likely causative agent is:

A. Giardia lamblia
B. Cyclospora cayetanensis
C. Cryptosporidium parvum
D. Entamoeba histolytica

Answer: A

NEW QUESTION # 48
A research laboratory is investigating the mechanisms of viral latency in herpes simplex virus type 1 (HSV-
1). During latency in sensory neurons, the viral genome exists as a circular episome. Whichof the following viral gene products is thought to play a crucial role in maintaining this latent state and preventing viral gene expression?

A. Late (L) proteins such as structural glycoproteins.
B. Immediate-early (IE) proteins such as ICP4 and ICP27.
C. Latency-associated transcripts (LATs).
D. Early (E) proteins such as thymidine kinase and DNA polymerase.

Answer: C

NEW QUESTION # 49
......

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